| 产品详情 |
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| Antigenic Specificity | CD369 (Dectin-1/CLEC7A) |
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| Clone | 15E2 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE anti-human CD369 (Dectin-1/CLEC7A). CD369 (Dectin-1), also known as CLEC7A and beta-glucan receptor (BGR), is a 33 kD type II transmembrane C-type lectin. It consists of a C-terminal stalk with a carbohydrate recognition domain (CRD) in the extracellular domain, a transmembrane segment, and a short N-terminal ITAM containing a cytoplasmic tail. CLEC7A is predominantly expressed on dendritic cells. Subsequent work has shown expression on B cells, monocytes, eosinophils, mast cells, macrophages, endothelial cells, and low expression on some subsets of T cells. CLEC7A lacks residues involved in calcium ligation that mediates carbohydrate-binding by classical C-type lectins. CLEC7A functions as a receptor to mediate innate immunity to fungal pathogens by selectively binding beta-glucan polymers, a major component of yeast and mycobacterial cell walls. |
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| Immunogen | Ectodomain with C-term hFc fusion, RIBLS. |
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| Other Names | CLECSF12, Dectin 1, beta-glucan receptor (BFR), Dectin1, CD369 |
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| Gene, Accession # | Gene ID: 64581 |
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| Catalog # | 355403 |
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| Price | |
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| Order / More Info | CD369 (Dectin-1/CLEC7A) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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