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| Product Name | SCH 51344 |
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| Description | Potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells. Purity 99%. MW (observed): 316.35 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol |
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| Gene, Accession, CAS # | CAS: 171927-40-5 |
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| Catalog # | 5280/50 |
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| Order / More Info | SCH 51344 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24695225 |
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| 产品资料 |
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