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| Product Name | Integrin alphaL, beta2, Recombinant, Human (LFA-1, CD11a/CD18) |
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| Description | Purity ~95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤1EU/ug (LAL). Integrin alphaLbeta2 is one of three beta2 integrin adhesion proteins. The non-covalent heterodimer of 180kD aL/CD11a and 95kD b2/CD18 integrin subunits is expressed on virtually all leukocytes. The ligand binding site of LFA-1 is in the N-terminal head region, formed by an interaction of the vWFA (I, I-like) domains from each subunit, and the aL betapropeller structure. The aL subunit contains domains termed thigh, calf-1 and calf-2, while the b2 subunit contains a PSI region and four cysteine-rich I-EGF folds. Each subunit has a transmembrane sequence and a short cytoplasmic tail connected to the cytoskeleton. Upon activation by ``inside-out'' signaling, clustering, or Mg2+ or Mn2+ binding to metal ion-dependent adhesion sites within the vWFA domains, the molecule unfolds from its inactive, ``closed'' conformation to expose ligand binding sites. Active aLb2 binds ICAM-1/CD54, ICAM-2, ICAM-3 |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3683, SwissProt: P20701, P05107 |
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| Catalog # | I7661-36R |
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| Order / More Info | Integrin alphaL, beta2, Recombinant, Human (LFA-1, CD11a/CD18) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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