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| Product Name | Integrin alphaM, beta2, Recombinant, Human (Mac-1, CD11b/CD18) |
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| Description | Purity ~95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤ 1EU /ug (LAL). DNA sequences encoding the extracellular domain of human Integrin alpha M (Phe 17-Asn 1104; Accession# P11215) (Corbi, A.L., et al., 1988, J. Biol. Chem. 263:12403) with an acid tail at the C-terminus and the extracellular domain of human Integrin b2 (Gln 22-Asn 700; Accession# P05107) (Kishimoto, T. et al., 1987, Cell 48:681) with a basic tail at the C-terminus were cloned downstream of the human CD33 signal peptides and co-expressed in Chinese hamster ovary (CHO) cells. Specifictity: The 1088aa human aM/CD11b ECD shares 73-76% aa sequence identity with mouse, rat, bovine and canine aM while the 678aa human b2/CD18 ECD shares 81-83% aa sequence identity with mouse, rat, bovine, canine, goat, sheep, and porcine b2. Molecular Mass: Based on N-terminal sequencing, the recombinant human Integrin aM subunit starts at Phe 17 and has a calculated molecular mass of ~124 |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3684, Accession: NP_001139280, SwissProt: P05107 |
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| Catalog # | I7661-37Y1 |
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| Order / More Info | Integrin alphaM, beta2, Recombinant, Human (Mac-1, CD11b/CD18) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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