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| Product Name | Mindbomb Homolog 1 (MIB1) Recombinant, Human |
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| Description | Purity ≥95%. Mindbomb homolog 1 (MIB1) is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged (1,2). MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase (DAPK1) in vitro (3). Expression of MIB1 is seen in both adult and embryonic murine tissues (4). Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins (cFLIP-L and cFLIP-S), which reduces the interaction of caspase-8 with cFLIP and leads to cell death (5). MIB1 is also involved in T and marginal zone B (MZB) cell development in the lymphopoietic niches (6). Source: Recombinant Human from E. coli Purity: ≥95% Endotoxin: 1.0EU per 1ug (determined by the LAL method) Accession No: Q86YT6 Fragment: Arg769~Glu1000 (Accession No: Q86YT6) Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- RN KKGQSPLDLC PDPNLCKALA KCHKEKVSGQ VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIA |
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| Size | 10ug, 50ug, 200ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q86YT6 |
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| Catalog # | 155877 |
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| Order / More Info | Mindbomb Homolog 1 (MIB1) Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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