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| Antigenic Specificity | Amiloride-Sensitive Cation Channel 3 (ACCN3) (aa 450-490) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.Subunit: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.Tissue specificity: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.Developmental stage: Expressed in fetal tissues, expression increases in lung and kidney adult tissues. Also known as: Amiloride-sensitive cation channel 3, Acid-sensing ion channel 3, ASIC3, hASIC3, Testis sodium channel 1, hTNaC1, TNaC1, SLNAC1, ACCN3, TNAC1. |
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| Immunogen | A synthetic peptide from aa region 450-490 of human ASIC3 conjugated to blue carrier protein was used as the antigen. |
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| Other Names | ACCN3|Accn3|DRASIC|SLNAC1|TNaC1|AW742291|TNAC1 |
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| Gene, Accession # | Gene ID: 9311 |
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| Catalog # | ABIN350050 |
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| Price | |
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| Order / More Info | Amiloride-Sensitive Cation Channel 3 (ACCN3) (aa 450-490) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9744806, 10842183, 9886053, 11587714, 9571199 |
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