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| Product Name | Recombinant Human C-C motif chemokine 5 (CCL5) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 11.9kDa. Full Length of Mature Protein: 24-91aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Choattractant for blood monocytes, mory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES (3-68) acts as a natural chotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES (4-68) exhibits reduced chotactic and HIV-suppressive activity compared with RANTES (1-68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | EoCPEosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5T cell-specific protein P228; TCP228T-cell-specific protein RANTES |
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| Gene, Accession, CAS # | CCL5, UniProt: P13501 |
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| Catalog # | RPC24103 |
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| Order / More Info | Recombinant Human C-C motif chemokine 5 (CCL5) from BIOMATIK |
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| Product Specific References | n/a |
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