| Edit |   |
|---|
| Antigenic Specificity | LRRFIP2 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 1:200-1:500 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | LRRFIP2 Polyclonal Antibody. Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of β-catenin and activate β-catenin/LEF/TCF-dependent transcriptional activity. A dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Fl |
|---|
| Immunogen | n/a |
|---|
| Other Names | HUFI-2; LRR FLII-interacting protein 2; leucine-rich repeat flightless-interacting protein 2 |
|---|
| Gene, Accession # | Entrez: 9209; Uniprot: Q9Y608 |
|---|
| Catalog # | PA5-57481 |
|---|
| Price | |
|---|
| Order / More Info | LRRFIP2 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|