| 产品详情 |
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| Antigenic Specificity | PD-1 |
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| Clone | J43 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | biotin conjugate |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 2.0 µg/1x10^6 cells |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PD-1 Monoclonal Antibody (J43), Biotin. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ``danger signals'' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune system |
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| Immunogen | n/a |
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| Other Names | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, programmed cell death protein 1, protein PD-1 |
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| Gene, Accession # | Entrez: 18566; Uniprot: Q02242 |
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| Catalog # | PA5-35009 |
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| Price | |
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| Order / More Info | PD-1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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