| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | p53 |
|---|
| Clone | 4A8 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | p53 Monoclonal Antibody (4A8). The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilizati |
|---|
| Immunogen | n/a |
|---|
| Other Names | antigen NY-CO-13, cellular tumor antigen p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TP53 |
|---|
| Gene, Accession # | Entrez: 7157; Uniprot: P04637 |
|---|
| Catalog # | MA5-15510 |
|---|
| Price | |
|---|
| Order / More Info | p53 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|