| 产品详情 |
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| Antigenic Specificity | p53 |
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| Clone | PAb 240 |
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| Host Species | Mouse |
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| Reactive Species | human, rhesus monkey |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | ChIP assay: 1-3 µg x 10^6 cells, Flow Cytometry: Assay Dependent, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p53 Monoclonal Antibody (PAb 240). The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabili |
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| Immunogen | n/a |
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| Other Names | antigen NY-CO-13, cellular tumor antigen p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TP53 |
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| Gene, Accession # | Entrez: 7157, 716170; Uniprot: P04637, P56424 |
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| Catalog # | MA5-15244 |
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| Price | |
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| Order / More Info | p53 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11551406, 11714701, 11955650, 12118068, 12370314, 12590363, 12730677, 12841870, 13679208, 14525955, 14990695, 14999779, 15254196, 15289314, 15330502, 15576338, 15610484, 15695381, 16264192, 16309219, 16489269, 16759149, 16888648, 17224908, 17363963, 17452983, 17595763, 17616682, 17644448, 17653608, 17805549, 18167185, 18533991, 18729252, 19010925, 19027820, 19394332, 19854077, 20063202, 20164600, 20521348, 20832752, 21062935, 22103910, 22174618, 22198862, 22217299, 22227037, 22553460, 22746246, 22813853, 23330981, 23392172, 24583641, 25664647, 26011298, 26192438 |
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