| 产品详情 |
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| Antigenic Specificity | DIO1 |
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| Clone | 1E4 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: 10 ng/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DIO1 Monoclonal Antibody (1E4). The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather th |
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| Immunogen | n/a |
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| Other Names | DIO1; ITDI1; TXDI1 |
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| Gene, Accession # | Entrez: 1733; Uniprot: P49895 |
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| Catalog # | MA5-24403 |
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| Price | |
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| Order / More Info | DIO1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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