| 产品详情 |
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| Antigenic Specificity | MTM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, guinea pig, human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1.0 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MTM1 Polyclonal Antibody. Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P. |
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| Immunogen | n/a |
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| Other Names | MTM1; myotubular myopathy 1; CNM; MTMX; XLMTM; myotubularin; myotubularin 1 |
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| Gene, Accession # | Entrez: 100069680, 100722582, 17772, 288762, 4534, 533622, 612385; Uniprot: A6QLT4, Q13496, Q6AXQ4, Q9Z2C5 |
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| Catalog # | PA5-70186 |
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| Price | |
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| Order / More Info | MTM1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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