| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human TNFRSF9/4-1BB-Fc Chimera (carrier-free) |
|---|
| Description | TNFRSF9, also known as 4-1BB and CD137, is a member of the tumor necrosis factor receptor superfamily (TNFRSF). It is a costimulatory receptor similar to OX40, CD27, CD30, and CD40. The interaction of TNFRSF9 and its ligand, TNFSF9, leads to the activation of cytotoxic T cells, reactivation of anergic T lymphocytes, and induces T cell proliferation. TNFRSF9/TNFSF9 preferentially enhances the expansion of CD8+ T cells rather than CD4+ T cells, through the increase of IL-2Rα (CD25) and IL-2 expressions in CD8+ T cells. Among the TNFRSF members, TNFRSF9 is the most potent inducers of IL-2Rα expression on CD8+ T cells. In vivo studies with TNFSF9 knockout mice and with the agonistic anti-TNFRSF9 monoclonal antibody showed that TNFRSF9/TNFSF9 interaction keeps optimal CD8 T-cell mediated immune response against viral infections and tumors. The mouse TNFRSF9 has 60% identity to the human receptor at the amino acid level. |
|---|
| Size | 500 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | CD137, CDw137, 4-1BB, 4-1BB ligand receptor, T cell antigen ILA, T cell antigen 4-1BB homolog. |
|---|
| Gene, Accession, CAS # | Gene ID: 3604 |
|---|
| Catalog # | 772608 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human TNFRSF9/4-1BB-Fc Chimera (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|