| 产品详情 |
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| Product Name | GSK690693 |
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| Description | Purity >95%. pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 < 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GSK-690693 |
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| Gene, Accession, CAS # | CAS: 937174-76-0 |
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| Catalog # | LS-H672 |
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| Price | |
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| Order / More Info | GSK690693 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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