| 产品详情 |
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| Product Name | GSK3326595 |
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| Description | A PRMT5 inhibitor; inhibits methylation of peptides derived from histones H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex (IC50s = 5.9-19.7 nM); more than 4,000-fold selective for PRMT5/MEP50 over a panel of 20 methyltransferases; induces alternative splicing of MDM4 in Z-138, MCF-7, JM1, and DOHH-2 cells at 200 nM; increases p53 and p21 protein levels in Z-138 cells in a concentration-dependent manner; inhibits growth and SDMA methylation in several lymphoma and breast cancer cell lines; reduces tumor growth in a Z-138 mouse xenograft model at 25, 50, and 100 mg/kg twice per day |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CAS: 1616392-22-3 |
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| Catalog # | 27305-10 |
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| Price | |
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| Order / More Info | GSK3326595 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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