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| Product Name | Carbonic Anhydrase IX/XII Inhibitor II, U-104 (CAIX Inhibitor II) |
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| Description | Purity ~98% (HPLC). A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (KiEnM and 4.5nM, respectively) against two other physiologically relevant hCA isoforms (KiP80nM and 9640nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells. Formula: C13H12FN3O3S Molecular Weight: 309.3 Solubility: DMSO (50mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217248 |
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| Order / More Info | Carbonic Anhydrase IX/XII Inhibitor II, U-104 (CAIX Inhibitor II) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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