| 产品详情 |
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| Antigenic Specificity | SIK2 |
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| Clone | 4C6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunofluorescence: 10 µg/mL, Western Blot: 1-5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIK2 Monoclonal Antibody (4C6). Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation. |
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| Immunogen | n/a |
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| Other Names | SIK2, Salt-inducible protein kinase 2, Serine, threonine-protein kinase SNF1-like kinase 2, SNF1LK2, QIK, LOH11CR1I |
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| Gene, Accession # | Entrez: 23235; Uniprot: Q9H0K1 |
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| Catalog # | MA5-21433 |
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| Price | |
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| Order / More Info | SIK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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