| 产品详情 |
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| Product Name | CFTR Activator, Cact-A1 |
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| Description | Purity ~98% (HPLC). A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50 = 1.6uM in CFTR-expressing Fisher rat thyroid cells). Also shown to activate deltaF508-CFTR in primary CF-HBE cell cultures (EC50 = 3.5uM). Reported to directly bind to the same site as CFTRinh-172. Does neither elevate intracellular cAMP levels nor appear to have any requirement for cAMP agonist, such as forskolin. Shown to additively potentiate the G551D-CFTR Cl- current activated by forskolin with CFTR potentiator, VX-770. Exerts no effect on either Ca2+-activated Cl- channel (TMEM16A) or intracellular Ca2+ levels. Solubility: DMSO Primary Target: CFTR |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CFTR Activator, Cact-A1 (5-((Z)-2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-3-amino-1H-pyrazole-4-carbonitrile, (Z)-3-(2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-5-amino-1H-pyrazole-4-carbonitrile, Cystic Fibrosis Transmembrane Conductance Regulator Activator, Cact-A1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217269 |
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| Order / More Info | CFTR Activator, Cact-A1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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