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| Product Name | Granzyme B Inhibitor Screening BioAssay™ Kit (Fluorometric) |
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| Description | Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. Intended Use: Used for screening Granzyme B inhibitors, characterize and study Granzyme B inhibitors. Test Principle: In the Granzyme B Inhibitor Screening BioAssay™ Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500nm. In the presence of potent Granzyme B Inhibitor, the hydrolyzation of substrate will be impeded. The Kit provides a rapid, simple, sensitive, and reliable |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 167845 |
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| Order / More Info | Granzyme B Inhibitor Screening BioAssay™ Kit (Fluorometric) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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