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| Product Name | Recombinant Human RISC-loading complex subunit TARBP2 (TARBP2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 66kDa. Full Length: 1-366aa. N-terminal GST-tagged. Homo sapiens (Human). Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein |
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| Gene, Accession, CAS # | TARBP2, UniProt: Q15633 |
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| Catalog # | RPC23040 |
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| Order / More Info | Recombinant Human RISC-loading complex subunit TARBP2 (TARBP2) from BIOMATIK |
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| Product Specific References | n/a |
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