| 产品详情 |
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| Product Name | Ikarugamycin |
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| Description | Purity >99%. Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity. It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases. It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 µM. Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione |
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| Gene, Accession, CAS # | CAS: 36531-78-9 |
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| Catalog # | LS-H8179 |
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| Price | |
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| Order / More Info | Ikarugamycin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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