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| Product Name | Recombinant Mouse Stromal cell-derived factor 1 (Cxcl12), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 12kDa. Partial: 22-89aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). Choattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chotaxis. Also binds to atypical chokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during bryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; TPAR1C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; PBSFThymic lymphoma cell-stimulating factor; TLSF |
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| Gene, Accession, CAS # | Cxcl12, UniProt: P40224 |
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| Catalog # | RPC24218 |
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| Order / More Info | Recombinant Mouse Stromal cell-derived factor 1 (Cxcl12), partial from BIOMATIK |
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| Product Specific References | n/a |
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