| 产品详情 |
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| Antigenic Specificity | Presenilin 1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Presenilin 1 Polyclonal Antibody. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different is |
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| Immunogen | n/a |
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| Other Names | AD3, FAD, PS-1, PS1, S182, presenilin-1 |
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| Gene, Accession # | Entrez: 19164, 5663; Uniprot: P49768, P49769 |
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| Catalog # | PA5-30585 |
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| Price | |
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| Order / More Info | Presenilin 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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