| 产品详情 |
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| Antigenic Specificity | Presenilin 1 |
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| Clone | polyclonal |
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| Host Species | Chicken |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Presenilin 1 Polyclonal Antibody. Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predominantly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions o |
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| Immunogen | n/a |
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| Other Names | PS1, PS-1, S182 protein |
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| Gene, Accession # | Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887 |
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| Catalog # | PA1-1752 |
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| Price | |
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| Order / More Info | Presenilin 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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