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| Antigenic Specificity | Presenilin-2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:200-1:800, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Presenilin-2 Polyclonal Antibody. Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predominantly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions o |
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| Immunogen | n/a |
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| Other Names | PS2, AD4, Alzheimer disease 4, PS2, PSEN 2, STM2 |
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| Gene, Accession # | Entrez: 5664; Uniprot: P49810 |
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| Catalog # | A304-342A-T |
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| Price | |
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| Order / More Info | Presenilin-2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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