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| Product Name | DR6, Cytoplasmic Domain, Recombinant, Human, aa371-655, His-Tag |
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| Description | Purity ~95%. Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines. Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence. Source: Recombinant |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DR6, Cytoplasmic Domain, Recombinant, Human, aa371-655, His-Tag (Death Receptor 6, BM018, MGC31965, TNFR Related Death Receptor 6, Tumor Necrosis Factor Receptor Superfamily Member 21, Tumor Necrosis Factor Receptor Superfamily Member 21 Precursor, TNFRSF21) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149782 |
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| Order / More Info | DR6, Cytoplasmic Domain, Recombinant, Human, aa371-655, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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