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| Product Name | Recombinant Human C-C motif chemokine 14 protein (CCL14) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 17.26kDa. Full Length of Mature Protein: 26-177aa. tag-Free. Homo sapiens (Human). Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-1 Receptor Antagonist Protein; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 Inhibitor; Anakinra; IL1RN; IL1F3; IL1RA |
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| Gene, Accession, CAS # | IL1RN, UniProt: P18510 |
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| Catalog # | RPC26906 |
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| Order / More Info | Recombinant Human C-C motif chemokine 14 protein (CCL14) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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