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| Product Name | Recombinant Human C-C motif chemokine 15 protein (CCL15) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 24.4kDa. Extracellular Domain: 26-232aa. C-terminal 6xHis-tagged. Homo sapiens (Human). Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra, generated by alternate splicing or proteolysis, retain ligand binding properties and inhibit IL-4 bioactivity. IL4-Ra is a component of two distinct receptor complexes and shows species selectivity between human and mouse. It can associate with the common gamma chain (?c) to form the IL-4 responsive type I receptor in which ?c increases the affinity for IL-4 and enables signaling. It can alternatively associate with IL13-Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. The use of shared receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other cytokines that utilize ?c. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA |
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| Gene, Accession, CAS # | IL4R, UniProt: P24394 |
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| Catalog # | RPC26873 |
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| Order / More Info | Recombinant Human C-C motif chemokine 15 protein (CCL15) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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