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| Product Name | Recombinant Human C-C motif chemokine 22 protein (CCL22) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 15.8kDa. Full Length of Mature Protein: 24-164aa. tag-Free. Homo sapiens (Human). Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN? on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-31; IL-31; IL31 |
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| Gene, Accession, CAS # | IL31, UniProt: Q6EBC2 |
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| Catalog # | RPC26909 |
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| Order / More Info | Recombinant Human C-C motif chemokine 22 protein (CCL22) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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