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| Product Name | Recombinant Human C-C motif chemokine 25 protein (CCL25) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 54.4kDa. Heterodimer: 20-189aa & 23-328aa. C-terminal 6xHis-tagged. Homo sapiens (Human). Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2 |
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| Gene, Accession, CAS # | IL-23, UniProt: Q9NPF7 & P29460 |
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| Catalog # | RPC26912 |
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| Order / More Info | Recombinant Human C-C motif chemokine 25 protein (CCL25) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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