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| Product Name | Recombinant Human ANG-2 Protein |
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| Description | ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an α helix rich ``coiled coil'' N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 - 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | Angiopoietin-2;ANG-2;ANGPT2; ANGPT2 |
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| Gene, Accession, CAS # | ANGPT2, UniProt: O15123 |
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| Catalog # | PROTO15123 |
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| Order / More Info | Recombinant Human ANG-2 Protein from BOSTER BIO |
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| Product Specific References | n/a |
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