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| Antigenic Specificity | GAD67 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 0.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GAD67 Polyclonal Antibody. GAD67, a 67KDa protein, is a neuronal isoform of this enzyme predominantly expressed in human Brain. It consists of Pyridoxal 5'-phosphate binding site and conserved Cysteine residues which are vital for its activity and is inhibited due to phosphorylation. It has high binding affinity for the cofactor Pyridoxal-5'phosphate and its role has been implicated in normal Palate development. It is found to be associated with childhood onset schizophrenia and craniofacial malformations and has been identified as a major auto antigen and an auto-reactive T-cell target in IDDM. Deficiency of this enzyme leads to pyridoxine dependency along with epilepsy. It also might play a role in stiff main syndrome. |
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| Immunogen | n/a |
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| Other Names | Glutamic acid decarboxylase 67 |
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| Gene, Accession # | Entrez: 2571; Uniprot: Q99259 |
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| Catalog # | PA1-41138 |
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| Price | |
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| Order / More Info | GAD67 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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