| 产品详情 |
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| Antigenic Specificity | GADD45B |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, guinea pig, human, mouse, porcine, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (PFA fixed): 1:100, Immunohistochemistry: 2 µg/mL, Western Blot: 0.2-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GADD45B Polyclonal Antibody. Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45 beta and GADD 45 gamma, have been shown to be induced by environmentalstresses. GADD 45 beta and G |
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| Immunogen | n/a |
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| Other Names | Growth arrest and DNA-damage-inducible beta, DKFZP566B133, GADD45BETA, MYD118 |
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| Gene, Accession # | Entrez: 100059768, 100621090, 100730773, 17873, 299626, 4616, 485069, 618405; Uniprot: O75293, P22339, Q5E9A5 |
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| Catalog # | PA5-43160 |
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| Price | |
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| Order / More Info | GADD45B Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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