| 产品详情 |
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| Product Name | 2-APB |
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| Description | A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes. Purity 98%. MW (observed): 225.1 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Aminoethoxydiphenylborane |
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| Gene, Accession, CAS # | CAS: 524-95-8 |
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| Catalog # | 1224/50 |
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| Order / More Info | 2-APB from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 15653710, 15958164, 16399208, 17085536, 17652632, 18158336, 19074643, 19389388, 19458227, 19570026, 19741130, 20001453, 20445050, 20473382, 21503158, 21562303, 22129278, 22718277, 23143333, 23185493, 23333427, 23349021, 23457590, 23843509, 24121509, 24454845, 25037570, 25044785, 25180102, 25459299, 25505874, 25654762, 25698739, 25803863, 25933382, 26578971, 27345695, 27874032 |
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