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| Product Name | PRMT5/MEP50, Recombinant, Human, FLAG-Tag/His-Tag (HRMT1L5, IBP72, JBP1, SKB1) |
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| Description | Purity ~89% (SDS-PAGE). Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer. Source: Recombinant protein corresponding to aa2-end from human PRMT5/MEP50, fused to N-terminal FLAG-tag (PRMT5) and N-terminal His-tag (MEP50), co-expressed in Baculovirus infected Sf9 cell expression system. Molecular Weight: ~73kD (PRMT5), 37.5kD (MEP50) Assay Conditions: 50ul reaction mix (20mM phosphate buffer pH 7.4, 20uM S-adenosyl methionine, and 10-100ng methyltransferase PRMT5) add to the wells coated with the substrate. Incubate at room temperat |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_006109 (PRMT5), NM_024102 (MEP50), SwissProt: O14744 |
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| Catalog # | 377014 |
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| Order / More Info | PRMT5/MEP50, Recombinant, Human, FLAG-Tag/His-Tag (HRMT1L5, IBP72, JBP1, SKB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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