| 产品详情 |
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| Antigenic Specificity | PHD3 |
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| Clone | EG188e/d5 |
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| Host Species | Mouse |
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| Reactive Species | human, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 200 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:400, Western Blot: 10 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PHD3 Monoclonal Antibody (EG188e/d5). HIF prolyl hydroxylase 3 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HIF prolyl |
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| Immunogen | n/a |
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| Other Names | HIFPH3, PHD3, HIF prolyl hydroxylase 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, egl nine homolog 3, egl nine-like protein 3 isoform, hypoxia-inducible factor prolyl hydroxylase 3, prolyl hydroxylase domain-containing protein 3 |
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| Gene, Accession # | Entrez: 112399, 54702; Uniprot: Q62630, Q9H6Z9 |
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| Catalog # | MA5-16144 |
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| Price | |
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| Order / More Info | PHD3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 28356975 |
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