| 产品详情 |
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| Antigenic Specificity | CNOT4 |
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| Clone | OTI1H2 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CNOT4 Monoclonal Antibody (OTI1H2). CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal. Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damag |
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| Immunogen | n/a |
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| Other Names | CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4 (negative regulator of transcription 4, yeast) homolog, potential transcriptional repressor NOT4Hp |
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| Gene, Accession # | Entrez: 4850; Uniprot: O95628 |
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| Catalog # | MA5-26382 |
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| Price | |
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| Order / More Info | CNOT4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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