| 产品详情 |
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| Product Name | Recombinant Human Phosphatidylcholine-sterol acyltransferase (LCAT), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 50.3kDa. Partial: 25-433aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Central enzyme in the Extracellular domain metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for rodeling high-density lipoprotein particles into their spherical forms. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Lecithin-cholesterol acyltransferasePhospholipid-cholesterol acyltransferase |
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| Gene, Accession, CAS # | LCAT, UniProt: P04180 |
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| Catalog # | RPC24265 |
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| Order / More Info | Recombinant Human Phosphatidylcholine-sterol acyltransferase (LCAT), partial from BIOMATIK |
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| Product Specific References | n/a |
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