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| Product Name | TNF-alpha Extracellular Domain, Human Recombinant |
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| Description | Purity > 95% by SDS - PAGE, MW: 18 kDa with a 6*His tag at the C-terminus. Tumor Necrosis Factor-α (TNF-α) is a highly pleiotropic cytokine with multiple activities other than its originally discovered role of tumor necrosis in rodents. It contributes to both inflammations during infections and anti-inflammatory/tissue repair processes after clearance of infection. TNF-α is mainly produced by activated macrophages, T lymphocytes, and natural killer (NK) cells. The activity of TNF-α is mediated through two cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75) that differ in their signaling activity. TNF-α's primary role is in the regulation of immune cells. It can induce cell death of certain tumor cell lines. About 28% of cancers are susceptible to direct cell killing mediated by soluble TNF-α. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2 |
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| Gene, Accession, CAS # | TNFA, Gene ID: 7124, Accession: P01375 |
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| Catalog # | P1395-50 |
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| Order / More Info | TNF-alpha Extracellular Domain, Human Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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