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| Product Name | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 64.5kDa. Full length of Isoform 2: 1-415aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns (4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating bryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete mbrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-11 |
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| Gene, Accession, CAS # | PLCZ1, UniProt: Q86YW0 |
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| Catalog # | RPC23255 |
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| Order / More Info | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) from BIOMATIK |
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| Product Specific References | n/a |
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