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| Product Name | Plasminogen Activator Inhibitor Type 1, Human, Recombinant (PAI 1) |
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| Description | Purity ~98% (SDS-PAGE gel electrophoresis). The cardiovascular risk factor plasminogen activator inhibitor type 1 (PAI 1) has been associated with abdominal obesity, hypertension, hypertriglyceridemia, hyperinsulinemia, glucose intolerance, and type II diabetes, conditions known to be linked with insulin resistance. Plasminogen activator inhibitor 1 (PAI 1) is a member of the serine protease inhibitor (serpin) superfamily and a central regulatory protein in the blood coagulation system. PAI-1 is unique among serpins in exhibiting distinct active and inactive (latent) conformations in vivo. Human PAI 1 is a single-chain glycoprotein with a molecular weight of 43kD. This inhibitor acts as ``bait'' for tissue-type and urokinase-type plasminogen activators (tPA and uPA) and protein C. Its rapid interaction with tPA may function as a major control point in the regulation of fibrinolysis. The highly mobile reactive-center loop (RCL) is thought to account for both the rapid inhibiton of plasmin |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_000602, SwissProt: P05121 |
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| Catalog # | P4256-29 |
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| Order / More Info | Plasminogen Activator Inhibitor Type 1, Human, Recombinant (PAI 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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