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| Product Name | Plasminogen Activator Inhibitor Type 1, Human, stable mutant (PAI-1) (Biotin) |
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| Description | Purity ~98% by SDS PAGE 95 (+/-) 5% active by uPA titration. Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Solubility: >2mg/ml and <5mg/ml Kinetic Data: Second order rate constants for inhibition of: UPA = 6.3 X 10e6 M^-1s^-1 tPA = 5.7 X 10e6 M^-1s^-1 |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4256-29K |
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| Order / More Info | Plasminogen Activator Inhibitor Type 1, Human, stable mutant (PAI-1) (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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