| 产品详情 |
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| Product Name | Pifithrin-a hydrobromide |
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| Description | Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). Cyclic analog available (Cat. No. 3843). MW (observed): 367.3. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide |
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| Gene, Accession, CAS # | CAS: 63208-82-2 |
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| Catalog # | 1267/10 |
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| Order / More Info | Pifithrin-a hydrobromide from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 16288207, 25938491, 29180572 |
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| 产品资料 |
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