| 产品详情 |
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| Product Name | PD 407824 |
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| Description | An inhibitor of Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively); selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM) and Cdk4 (IC50 = 3.75 µM); selective for Chk1 and WEE1 over c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other Cdks (IC50s = >50 µM); sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin at 0.5 µM; induces myoblast differentiation into mature osteoblasts and hESC differentiation into cells with mesoderm or cytotrophoblast stem cell lineages when used in combination with BMP4 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PD407824 0407824 PD0407824 chk-1 wee-1 cSrc SKOV-3 SKOV3 OVCAR3 A-2780 BMP-4 SK-OV3 Cdk-4 C2-C12 C-2C12 C2C-12 C-2C-12 |
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| Gene, Accession, CAS # | CAS: 622864-54-4 |
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| Catalog # | 25989-1 |
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| Price | |
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| Order / More Info | PD 407824 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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