| 产品详情 |
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| Antigenic Specificity | SIRT1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:10-1:500, Immunofluorescence: 1:10-1:500, Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIRT1 Polyclonal Antibody. SIRT1, the human homolog of the S. cerevisiae Sir2 protein, functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage, SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuate p53-mediated functions. When overexpressed in mouse embryo fibroblasts, SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells, SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors. |
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| Immunogen | n/a |
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| Other Names | RP11-57G10.3, SIR2L1, NAD-dependent deacetylase sirtuin-1, SIR2-like protein 1, SIR2alpha, hSIR2, hSIRT1, sir2-like 1, sirtuin type 1 |
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| Gene, Accession # | Entrez: 23411; Uniprot: Q96EB6 |
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| Catalog # | PA5-23063 |
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| Price | |
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| Order / More Info | SIRT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 27586459 |
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| 产品资料 |
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