| 产品详情 |
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| Antigenic Specificity | ICAD |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:100 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ICAD Polyclonal Antibody. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released f |
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| Immunogen | n/a |
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| Other Names | DFF-45, DFF1, ICAD, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, inhibitor of CAD |
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| Gene, Accession # | Entrez: 1676; Uniprot: O00273 |
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| Catalog # | PA1-37559 |
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| Price | |
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| Order / More Info | ICAD Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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