| 产品详情 |
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| Antigenic Specificity | GRB14 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GRB14 Polyclonal Antibody. Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. An additional m |
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| Immunogen | n/a |
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| Other Names | Growth factor receptor-bound protein 14; GRB14 adapter protein |
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| Gene, Accession # | Entrez: 2888, 50915, 58844; Uniprot: O88900, Q14449, Q9JLM9 |
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| Catalog # | PA5-75399 |
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| Price | |
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| Order / More Info | GRB14 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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