| 产品详情 |
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| Product Name | GNF-5 |
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| Description | Purity >95%. Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2 , a selective allosteric inhibitor of Bcr-Abl. GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively. When used in combination with the ATP-competitive Bcr-Abl inhibitors imatinib or nilotinib , GNF-5 displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse bone marrow transplantation model. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2-hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide |
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| Gene, Accession, CAS # | CAS: 778277-15-9 |
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| Catalog # | LS-H7973 |
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| Order / More Info | GNF-5 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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