| 产品详情 |
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| Antigenic Specificity | MCL1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 10 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MCL1 Polyclonal Antibody. Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death. |
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| Immunogen | n/a |
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| Other Names | BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT; bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; induced myeloid leukemia cell differentiation protein Mcl-1; myeloid cell leukemia ES |
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| Gene, Accession # | Entrez: 17210, 4170, 60430; Uniprot: P97287, Q07820, Q9Z1P3 |
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| Catalog # | PA5-20120 |
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| Price | |
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| Order / More Info | MCL1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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